Bag-3 Polyclonal Antibody
簡要描述:Bag-3 Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應(yīng)性: Human;Rat;Mouse;應(yīng)用: WB;IHC;IF;ELISAWB:蛋白質(zhì)印跡法 IHC-P:石蠟切片樣本的免疫組織化學(xué)法 IHC-F:冰凍切片樣本的免疫組織化學(xué)法 ICC/IF:免疫細胞熒光 IP:免疫沉淀法 FC:流式細胞術(shù) ELISA:酶聯(lián)免疫吸附測定
產(chǎn)品型號: YP-Ab-00580
所屬分類:多克隆抗體
更新時間:2024-10-31
詳細說明:
Bag-3 Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),是一種能特異性結(jié)合抗原的糖蛋白,而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi),抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據(jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),每一個抗體的重鏈則決定了它的類或型。
產(chǎn)品詳情
Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
免疫原詳細信息
The antiserum was produced against synthesized peptide derived from the Internal region of human BAG3. AA range:311-360
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
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備注:圖片僅供參考。僅供科研,不可用于臨床。